Thus, the meta-analyses did not confirm the role of these variants in DTC etiology Tables 1 and 2. Furthermore, rs near NKX 14q The role of these loci in DTC etiology was already discussed in previous works and will be not discussed here. Overall, our in-depth analysis showed that some a priori hypotheses formulated in previous studies were confirmed and could have realistic bases for shedding some lights in the etiology of DTC.
SNPs previously studied in relation to DTC risks from genome-wide association studies or studies focused on specific intergenic regions Genetic variants on 1p The costs of publication of this article were defrayed in part by the payment of page charges. Landi Administrative, technical, or material support i.
When this result was combined in meta-analysis with seven previous studies carried out on Caucasians, an OR of 0. Thus, no significant evidence of association was identified in the meta-analysis using the random-effect model Table 2.
Typically these studies were performed according to candidate-gene approaches, and rarely the findings were replicated using similar samples in terms of ethnicity and thyroid carcinoma histological type. Received June 29, Although in the present work most of the SNPs assayed in previously published hypothesis-driven studies were not associated with the risk of DTC, it is noteworthy to observe that several of them actually did associate.
Furthermore, to date, only few GWASs were performed, and a small number of genomic loci were associated with the risk of the disease by using this approach.
In particular, we highlighted the role of rs and rs, whose association was not significant in previous studies but became statistically significant after increasing the sample size with the present meta-analysis. When the meta-analyses were extended to other available populations, four more SNPs showed an evidence of association, although not significantly after FDR correction: SNPs within immune response and inflammation genes Fifteen genes and 33 SNPs involved in immunity or in inflammation pathways were analyzed to identify susceptibility variants for DTC and eight significantly associated SNPs were published Table 1.
Section solely to indicate this fact.
Ideally, all these SNPs should be replicated in a large and independent series of cases and controls to further confirm their involvement in DTC predisposition SAMURAI: Sensitivity analysis of a meta-analysis with unpublished but registered analytical investigations (software).
As a meta-analysis problem, the disease status is the design factor for which we want to distinguish or compare the observations We can say that these are our treatments As we have mentioned, other design factors affecting the Meta-analysis of case-control studies. methods/technologies in the quality control of herbal medicinal products1F EMA/HMPC// Page 4/4 European Pharmacopoeia General Chapter 2 “Methods o f analysis”.
Methods: We combined the results from a genome-wide association study (GWAS) performed by our group and from published studies on DTC. With a first approach, we evaluated whether a SNP published as associated with the risk of DTC could replicate in our GWAS (using FDR as adjustment for multiple comparisons).
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